GSK682753A
规格
| Cas Number | 1334294-76-6 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 100 mg/mL (208.43 mM) |
| 过滤标签 | EBI2/GPR183,GPCR/G Protein |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | GSK682753A 是天疱疮病毒诱导受体 2（EBI2）的一种选择性强效反向激动剂，IC 50 为 53.6 nM。 |
| 英文描述 |
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 ( EBI2 ) with an IC 50 of 53.6 nM. In Vitro GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC 50 of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 53.6 nM (EBI2) |