GW806742X hydrochloride
规格
| Cas Number | G659343 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (163.93 mM; Need ultrasonic) H2O : ＜ 0.1 mg/mL (ultrasonic) (insoluble) |
| 过滤标签 | VEGFR,Mixed Lineage Kinase,Protein Tyrosine Kinase/RTK,MAPK/ERK Pathway |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 英文描述 |
GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl Appearance:Solid IC50& Target:MLKL|9.3 μM (Kd)|VEGFR2|2 nM (IC|50|) In Vitro:GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induce Biological Activity:GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl |