Hh-Ag1.5
规格
| Cas Number | 612542-14-0(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Hedgehog,Stem Cell/Wnt,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Hh-Ag1.5（SAg1.5）是一种强效的刺猬（Hh）激动剂，EC 50为1 nM。Hh-Ag1.5介导的重编程可打破非损伤肝干细胞的静止状态，从而挽救肝衰竭。 |
| 英文描述 |
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog ( Hh ) agonist with an EC 50 of 1 nM Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure . In Vitro HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133 + CD45 - liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the K i value of 0.52 nM. The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC 50 of 7 nM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:EC50: 1 nM (Hedgehog) |