HS 38,ATP竞争性DAPK和ZIPK抑制剂
规格
| Cas Number | 1030203-81-6 |
| 规格或纯度 | ≥98%(HPLC) |
| 纯度 | ≥98%(HPLC) |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 别名 | 2-[[1-(3-氯苯基)-4,5-二氢-4-氧代-1H-吡唑并[3,4-d]嘧啶-6-基]硫代]丙酰胺 |
| 品牌 | 阿拉丁 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 17.49, 最高浓度(mM): 50 |
| 简短描述 | ATP竞争性DAPK和ZIPK抑制剂 |
| 英文简短描述 | ATP-competitive inhibitor of DAPK and ZIPK |
| 过滤标签 | Apoptosis,DAPK |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DAPK（IC50 = 200 nM）和ZIPK（Kd = 280 nM）的ATP竞争性抑制剂。还抑制PIM3激酶（IC50 = 200 nM），但对Src或Abl激酶无明显影响。减少小鼠主动脉和兔子回肠组织中调节性肌球蛋白轻链和肌球蛋白轻链磷酸酶的磷酸化。 HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM, 89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinase, also called DAPK3) that regulate programmed cell death, and also inhibits the closely related PIM3 kinase (IC50 = 200 nM, 76% inhibition at 10 RM). In addition to mediating apoptosis, DAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscle, and decreased contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle. |