β-Hydroxyisovalerylshikonin
规格
| Cas Number | 7415-78-3 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 10 mg/mL (25.75 mM; ultrasonic and warming and heat to 60°C) |
| 英文简短描述 | Quinones Naphthalene Quinones Phenols Polyphenols |
| 过滤标签 | EGFR,Src,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK,Quinones Naphthalene Quinones Phenols Polyphenols |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Beta-hydroxyisovalerylshikonin 是一种从红豆杉（Lithospermum erythrorhizon）中分离出来的天然产物，是蛋白酪氨酸激酶（PTK）的强效抑制剂，对表皮生长因子受体（EGFR）和 v-Src 受体的 IC 50 s 分别为 0.7μM 和 1μM。Beta-hydroxyisovalerylsh |
| 英文描述 |
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon , acts as a potent inhibitor of protein tyrosine kinases (PTK) , with IC 50 s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells Form:Solid IC50& Target:IC50: 0.7 μM (EGFR), 1 μM (v-Src) |