IPI-3063
规格
| Cas Number | 1425043-73-7 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | p110δ 选择性抑制剂 |
| 英文简短描述 | p110δ Selective Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | IPI-3063 是一种强效的选择性 p110δ 抑制剂，其生化 IC50 值为 2.5\u2009±\u20091.2nM，而其他 I 类 PI3K 同工酶（p110α、p110β、p110γ）的 IC50 值至少高出 400 倍。 |
| 英文描述 |
Information IPI-3063 is a potent and selectivep110δinhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher. Targets p110δ (Cell-free assay) 2.5 nM In vitro IPI-3063 is a p110δ selective compound with an IC50\u2009=\u20090.1\u2009nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation. In vivo IPI-3063 has good pharmacokinetics in mice. Cell Research(from reference) Cell lines：purified mouse B cells Concentrations：0.01, 0.1, 1, 10, 30, 100\u2009nM Incubation Time：48 h |