icenticaftor
规格
| Cas Number | 1334546-77-8 |
| 规格或纯度 | Moligand™, ≥98% |
| 级别 | Moligand™ |
| 纯度 | ≥98% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 别名 | compound 33;QBW-251;QBW251 |
| 品牌 | 阿拉丁 |
| Action Type | 激活剂 |
| Mechanism Of Action | 囊性纤维化跨膜传导调节剂激活剂 |
| 溶解性 | DMSO: 150 mg/mL (415.24 mM), Sonification and heating to 60℃ are recommended. |
| 过滤标签 | CFTR,Membrane Transporter/Ion Channel |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 描述 |
Icenticaftor (QBW251) 是一种 CFTR 通道增强剂，F508del 和 G551D CFTR 的 EC50 分别为 79 nM 和 497 nM。Icenticaftor 可用于慢性阻塞性肺疾病 (COPD) 和囊性纤维化研究。 |
| 英文描述 |
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research. |