Idalopirdine Hydrochloride
规格
| Cas Number | 467458-02-2 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 2mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 25 mg/mL (57.49 mM) H2O : 2 mg/mL (4.60 mM; ultrasonic and warming and heat to 60°C) |
| 过滤标签 | 5-HT Receptor,GPCR/G Protein,神经元信号传导 |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | Idalopirdine Hydrochloride（Lu AE58054 Hydrochloride）是一种强效、选择性 5-HT6 受体拮抗剂，其 K i 值为 0.83 nM。Idalopirdine Hydrochloride 可用于阿尔茨海默病和精神分裂症以及其他相关疾病的研究[... |
| 英文描述 |
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K i value of 0.83 nM. Idalopirdine Hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders In Vivo Idalopirdine (intraperitoneal injection, 5 mg/kg, daily, 28 days) Hydrochloride can reduce food intake and body weight in over-eating rat models . Idalopirdine (1 or 2 mg/kg, i.v) Hydrochloride can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 5 mg/kg Administration: intraperitoneal injection, daily, 28 days Result: Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol. Animal Model: Male Sprague-Dawley ratsDosage: 1 or 2 mg/kg Administration: i.v. Result: No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg. Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration. Form:Solid IC50& Target:5-HT 6 Receptor 0.83 nM (Ki) |