INCB059872 dihydrochloride
规格
Cas Number | I659229 |
规格或纯度 | ≥98% |
纯度 | ≥98% |
包装 | 10mg 或 1mg 或 5mg |
产品信息
品牌 | 阿拉丁 |
溶解性 | DMSO : 3.57 mg/mL (7.77 mM; ultrasonic and warming and heat to 60°C) |
过滤标签 | 表观遗传学,Histone Demethylase |
储存温度 | 2-8°C储存,干燥 |
运输条件 | 冰袋运输 |
英文描述 |
INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia. Appearance:Solid IC50& Target:KDM1/LSD1 In Vitro:INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression. INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 days In Vivo:INCB059872 (10mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations. MCE has not independently confirmed the accuracy of these methods. They are for reference o Biological Activity:INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia. |