JNJ-9350
规格
| Cas Number | 326923-09-5 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 1mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 5 mg/mL (11.83 mM; ultrasonic and warming and heat to 60°C) |
| 过滤标签 | 表观遗传学,Histone Demethylase |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | JNJ-9350 是精胺氧化酶（SMOX）的抑制剂，其 IC 50 值为 0.01 μM。JNJ-9350 还能抑制多胺氧化酶（PAO），其 IC 50 值为 0.79 μM。JNJ-9350 可用于癌症研究。 |
| 英文描述 |
JNJ-9350 is an inhibitor of spermine oxidase ( SMOX ) with an IC 50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase ( PAO ) with an IC 50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer In Vitro JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC 50 values of 10 nM, 790 nM and ＞60 μM, respectively. JNJ-9350 (1.1-70 µM) binds with SMOX with a K i value of 9.9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 1.19 Pharmacokinetic Properties of JNJ-9350 in Mice . Mice PO 10 mg/kg Clearance (mL/min/kg) (Total/Unbound) 73/5217 Volume of distribution (L/kg) 1.7 Half-life (min) 16 PPB (Mouse) 98.6% Oral F% 34% MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 10 nM (SMOX), 790 nM (PAO), ＞60 μM (LSD1) |