JAK2-IN-6
规格
| Cas Number | 353512-04-6 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 60 mg/mL (178.66 mM; ultrasonic and adjust pH to 5 with HCl) |
| 过滤标签 | 表观遗传学,JAK,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK,Stem Cell/Wnt |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | JAK2-IN-6 是一种多取代氨基噻唑衍生物，是一种强效的选择性 JAK2 抑制剂，其 IC 50 为 22.86 μg/mL。JAK2-IN-6 对 JAK1 和 JAK3 没有活性。JAK2-IN-6 对癌细胞具有抗增殖作用。 |
| 英文描述 |
JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC 50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3 . JAK2-IN-6 has anti-proliferative effect against cancer cells In Vitro JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours; PC-9, H1975 and PANC-1 cells) treatment exhibits significantly antiproliferative activity against all of these cancer cell lines, with IC 50 values of 18.1 μg/mL, 58.3 μg/mL, 40.6 μg/mL against PC-9, H1975 and PANC-1, respectively. JAK2-IN-6 (Compound B2), an intramolecular hydrogen bond is formed, holding the chlorothiophene substituent coplanar with the aminothiazole core. The chlorothiophene moiety is found to be located in the binding pocket adjacent to Val863 and Leu983, and extends towards the Asp994 of activation loop and the Gly993 of glycine-rich loop. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PC-9, H1975 and PANC-1 cells Concentration: 6.3 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL Incubation Time: 48 hours Result: Exhibited significantly antiproliferative activity against all of these cancer cell lines. Form:Solid IC50& Target:JAK2 22.86 μg/mL (IC 50 ) |