Kushenol A
规格
| Cas Number | 99217-63-7 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (244.80 mM; Need ultrasonic) |
| 英文简短描述 | Flavonoids Flavonones Phenols Polyphenols |
| 过滤标签 | Tyrosinase,Glucosidase,Metabolic Enzyme/Protease,Flavonoids Flavonones Phenols Polyphenols |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Kushenol A（Leachianone E）是从 Sophora flavescent 的根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶抑制剂，可阻止 L- 酪氨酸向 L-DOPA 的转化，其 IC 50 和 K i 值分别为 1.1 μM 和 0.4 μM。草酚 |
| 英文描述 |
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent . Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC 50 and K i values of 1.1 μM and 0.4 μM, respectively Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase ( IC 50 : 45 μM; K i : 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging In Vitro Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM. Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: Exhibited considerable cytotoxic effects against NSCLC cells. Form:Solid IC50& Target:IC50: 1.1 μM (tyrosinase),45 μM (alpha-glucosidase) |