LIT-927
规格
| Cas Number | 2172879-52-4 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | CXCR4 选择性抑制剂 | 激动剂 | 拮抗剂 |
| 英文简短描述 | CXCR4 Selective Inhibitors | Agonists | Antagonists |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | LIT-927 是一种新型的 CXCL12 中性配体，抑制德克萨斯红标记的 CXCL12（CXCL12-TR）结合的 Ki 值为 267 nM。它对 CXCL12 和其他同样与哮喘有关的趋化因子具有高度选择性。 |
| 英文描述 |
Information LIT-927 is a novel neutraligand ofCXCL12with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma. Targets CXCR4 ; CXCL12 ; 267 nM(Ki) In vitro LIT-927 is able to bind selectively CXCL12 and to inhibit CXCL12-CXCR4 interaction. In vivo In a murine model of hypereosinophilia, LIT-927 shows a large and statistically reliable inhibition of eosinophil recruitment. It inhibits allergic eosinophilic airway inflammation in mice when administered orally or locally. |