LDC7559
规格
| Cas Number | 2407782-01-6(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Apoptosis,Pyroptosis,Immunology/Inflammation,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | LDC7559 是一种气敏 D（GSDMD）抑制剂，可在晚期阻断中性粒细胞胞外捕获器（NET）。 |
| 英文描述 |
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages In Vitro LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells. ?\nLDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Gasdermin D |