Lck inhibitor 2
规格
| Cas Number | 944795-06-6(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Src,Protein Tyrosine Kinase/RTK,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Lck 抑制剂 2 是一种双苯胺嘧啶类酪氨酸激酶抑制剂，包括 LCK、BTK、LYN、SYK 和 TXK。对 Lck、Btk、Lyn、Btk 和 Txk 的 IC50 值分别为 13nM、9nM、3nM、26nM 和 2nM \nIC50 值：13 nM（Lck） \nTarget：Src fam |
| 英文描述 |
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk , Lyn, Btk and Txk respectivelyIC50 Value: 13 nM(Lck) Target: Src family kinaseLck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). |