Litronesib
规格
| Cas Number | 910634-41-2(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| Action Type | 抑制剂 |
| Mechanism Of Action | 驱动蛋白样蛋白 1 抑制剂 |
| 过滤标签 | Kinesin,Cell Cycle/DNA Damage,Cytoskeleton,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Litronesib（LY2523355）是一种选择性有丝分裂特异性驱动蛋白 Eg5 抑制剂，具有抗肿瘤活性。 |
| 英文描述 |
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity In Vitro Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Eg5 |