LCL521 dihydrochloride
规格
| Cas Number | 1226759-47-2 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | H2O : 100 mg/mL (150.22 mM; Need ultrasonic) DMSO : 20.83 mg/mL (31.29 mM; Need ultrasonic) |
| 过滤标签 | Phospholipase,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | LCL521 二盐酸盐是一种酸神经酰胺酶（ACDase）抑制剂。LCL521 还能抑制溶酶体酸性鞘磷脂酶（ASMase）。 |
| 英文描述 |
LCL521 dihydrochloride is an acid ceramidase ( ACDase ) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase ( ASMase ) In Vitro LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:ACDase, ASMase |