LY2787106 (anti-Hepcidin)
规格
| Cas Number | |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 级别 | 无动物源,无载体,重组,ExactAb™,低内毒素,无叠氮钠,已验证 |
| 纯度 | ≥95%(SDS-PAGE&SEC-HPLC) |
| 包装 | 10mg 或 1mg 或 5mg 或 100μg |
产品信息
| 别名 | Hamp antibody; HEPC antibody; HEPC_HUMAN antibody; Hepc20 antibody; Hepc25 antibody; HEPCIDIN antibody; Hepcidin 20 antibody; Hepcidin 25 antibody; Hepcidin antimicrobial peptide antibody; Hepcidin-20 antibody; Hepcidin25 antibody; HFE2 antibody; HFE2B antibody; LEAP 1 antibody; LEAP-1 antibody; LEAP1 antibody; Liver expressed antimicrobial peptide antibody; Liver-expressed antimicrobial peptide 1 antibody; PLTR antibody; Putative liver tumor regressor antibody; HAMP; HEPC; hepcidin antimicrobial peptide; Hepcidin; HEPCPutative liver tumor regressor; HFE2B; HFE2Bhepcidin; LEAP1; LEAP-1; LEAP1PLTR; Liver-expressed antimicrobial peptide 1; PLTR |
| 品牌 | 阿拉丁 |
| 浓度 | 见COA |
| 简短描述 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 英文简短描述 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 稳定性和储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| 组织特异性 | Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. |
| 轻链类型 | kappa |
| 防腐剂（Preservatives） | No |
| 过滤标签 | Gene ID:57817,Accession#:P81172,Hepcidin,HAMP |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| Clonality | 重组抗体 |
| 形式 | Whole IgG |
| Accession ID | P81172 |
| 物理形态 | 液体 |
| 特异性 | HAMP |
| Species reactivity（Reacts with) | 人(Human) |
| Conjugate | Unconjugated |
| 纯化方法 | Protein A purified |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 亚型 | Human IgG4SP |
| Host species | 人(Human) |
| 靶标动物 | Human |
| 内毒素浓度 | <1.0 EU/mg |
| Source | CHO细胞培养上清 |
| 描述 |
LY2787106 (anti-Hepcidin)是一种针对 Hepcidin 的全人源化单克隆抗体。目前正处于癌症相关贫血的第一阶段人体试验中。它与铁调素结合并阻止其与铁输出蛋白铁转运蛋白结合，防止铁调素诱导的铁转运蛋白内化和降解，并增加铁转运蛋白介导的铁输出。 |
| 英文描述 |
LY2787106 (anti-Hepcidin) is a fully humanized monoclonal antibody againsts hepcidin. It is currently in phase I human trials for cancer-related anemia. It binds to hepcidin and prevents its binding to the iron exporting protein ferroportin and prevents hepcidin-induced internalization and degradation of ferroportin and increases ferroportin-mediated iron export. |
| SDS-PAGE | 144.22 kDa |