ML364
规格
| Cas Number | 1991986-30-1 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | USP/UBP 选择性抑制剂 |
| 英文简短描述 | USP/UBP Selective Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | ML364 是一种去泛素化酶 USP2 的小分子抑制剂，在使用内部淬灭荧光二泛素底物的生化试验中，其 IC50 值为 1.1 μM。 |
| 英文描述 |
Information ML364 is a small molecule inhibitor of thedeubiquitinase USP2with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Targets USP8 (Cell-free assay); USP2 (Cell-free assay) 0.95 μM; 1.1 μM In vitro ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest in Mino and HCT116 cancer cell lines. ML364 is antiproliferative in cancer cell lines. ML364 also causes a decrease in homologous recombination-mediated DNA repair. It is inactive against caspase 6, caspase 7, MMP1, MMP9, and USP15, but does inhibit USP8 with an IC50 of 0.95 μM. In a panel of 102 kinases that included regulators of the cell cycle there is no binding observed to any of the enzymes tested using 10 μM ML364. Cell Research(from reference) Cell lines：LnCAP cells and MCF7 cells Concentrations：0-20 μM Incubation Time：24 h |