MSX-122
规格
| Cas Number | 897657-95-3 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 别名 | N1,N4-二-2-嘧啶基-1,4-苯二甲胺 |
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| Action Type | 拮抗剂 |
| Mechanism Of Action | C-X-C 趋化因子受体 4 型拮抗剂 |
| 简短描述 | CXCR4 选择性抑制剂 | 激动剂 | 拮抗剂 |
| 英文简短描述 | CXCR4 Selective Inhibitors | Agonists | Antagonists |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | MSX-122 是一种新型小分子 CXCR4 部分拮抗剂（IC50~10 nM）。 |
| 描述 |
产品介绍： |
| 英文描述 |
Information MSX-122 is a novel small molecule and partialCXCR4antagonist (IC50~10 nM). Targets CXCR4 ~10 nM In vitro MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux). In vivo MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo. Cell Research(from reference) Cell lines：MDA-MB-231 cells Concentrations：1, 10, 100, and 1000 nM Incubation Time：15 mins |