M1002
规格
| Cas Number | 823830-85-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMF : 50 mg/mL (126.81 mM; Need ultrasonic) DMSO : 50 mg/mL (126.81 mM; ultrasonic and warming and heat to 60°C) |
| 过滤标签 | HIF/HIF Prolyl-Hydroxylase,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | M1002 是一种缺氧诱导因子-2（HIF-2）激动剂，可增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域（PHD）抑制剂具有协同作用。 |
| 英文描述 |
M1002 is a hypoxia-inducible factor-2 ( HIF-2 ) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors. In Vitro M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy. M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: 786-O cells Concentration: 10 μM Incubation Time: 24 hours Result: Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. RT-PCRCell Line: Hep3B cells Concentration: 5 μM Incubation Time: 24 hours Result: Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment. Form:Solid |