MB710
规格
| Cas Number | 2230044-57-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 16.67 mg/mL (36.45 mM; Need ultrasonic) |
| 过滤标签 | Apoptosis,MDM-2/p53 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | MB710 是一种氨基苯并噻唑衍生物，是致癌 p53 突变 Y220C 的稳定剂。MB710 与 Y220C 口袋紧密结合并稳定 p53-Y220C，其 K d 为 4.1u202fμM。MB710 在 p53-Y220C 细胞系中显示出抗癌活性。 |
| 英文描述 |
MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C . MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C , with a K d of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines In Vitro MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations. MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC 50 s of 90, 120, >120, >120 μM, respectively. MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT) Concentration: 0-200 μM Incubation Time: 72 hours Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line. Form:Solid IC50& Target:Kd: 4 μM (p53-Y220C) |