Mizacorat
规格
| Cas Number | 1893415-00-3 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (202.21 mM; Need ultrasonic) H2O : 0.67 mg/mL (1.35 mM; Need ultrasonic) |
| 过滤标签 | Glucocorticoid Receptor,Immunology/Inflammation,Vitamin D Related/Nuclear Receptor |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Mizacorat（AZD9567；化合物 15）是一种强效的口服活性非甾体选择性糖皮质激素受体调节剂（SGRM），IC 50 为 3.8 nM。在链球菌细胞壁（SCW）再活化关节炎模型中表现出卓越的疗效 |
| 英文描述 |
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation In Vivo Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model. Form:Solid IC50& Target:IC50: 3.8 nM (Glucocorticoid receptor) |