MMPI-1154
规格
| Cas Number | 1382722-47-5 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 83.33 mg/mL (187.05 mM; Need ultrasonic) |
| 过滤标签 | MMP,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | MMPI-1154 是一种很有前景的新型心肌细胞保护性咪唑羧酸（ICA）MMP-2 抑制剂（IC 50 =6.6 μM），可用于急性心肌梗死的研究。MMPI-1154 还能抑制 MMP-13、MMP-1 和 MMP-9 的活性，其 IC 50 = 6.6 μM |
| 英文描述 |
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor( IC 50 =6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13 , MMP-1 and MMP-9 with IC 50 s of 1.8 μM,10 μM, and 13 μM, respectively In Vitro MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM. MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MMP-2 6.6 μM (IC 50 ) MMP-13 1.8 μM (IC 50 ) MMP-1 10 μM (IC 50 ) MMP-9 13 μM (IC 50 ) |