Mtb ATP synthase-IN-1
规格
| Cas Number | 2642394-38-3 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 125 mg/mL (386.64 mM; Need ultrasonic) |
| 过滤标签 | ATP Synthase,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Mtb ATP合酶-IN-1（化合物6ab）是一种强效的结核分枝杆菌（Mtb）ATP合酶抑制剂，对Mtb的MIC为0.452-0.499 μg/mL。Mtb ATP 合成酶-IN-1 具有良好的代谢稳定性、较低的细胞毒性（Vero IC 50 > 64 μg/mL）和可接受的毒性。 |
| 英文描述 |
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis ( Mtb ) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb . Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC 50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium In Vivo Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability . Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse . PO (50 mg/kg) IV (5 mg/kg) C max (ng/mL) 1333 1241 T max (h) 0.83 T 1/2 (h) 0.51 0.33 AUC 0-t (ng/mL·h) 2197 1667 AUC 0-∞ (ng/mL·h) 2198 1672 MRT 0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mouse Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability. Form:Solid IC50& Target:MIC: 0.452-0.499 μg/mL ( Mtb ) |