MV1
规格
| Cas Number | 1001600-54-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 125 mg/mL (216.74 mM) |
| 过滤标签 | Apoptosis,IAP |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | MV1 是 IAP（细胞凋亡抑制蛋白）的拮抗剂，与 HaloTag 配体结合可导致 HaloTag 融合蛋白的蛋白敲除。 |
| 英文描述 |
MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand. In Vitro MV1 (0.08-20 μM; 24 h) inhibits the growth of EVSAT cells. MV1 (5 μM; 0-60 min) treatment causes rapid loss of c-IAP1 and c-IAP2 in MDA-MB-231 cells. MV1 (5 μM; 1 h) treatment inducing degradation of c-IAP1 and c-IAP2 is dependent on proteasomal machinery but not on caspase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: EVSAT cells Concentration: 0.08-20 μM Incubation Time: 24 hours Result: Showed IC 50 value of 5 μM for EVSAT cells. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 5 μM Incubation Time: 0-60 min Result: Showed the decreasement of c-IAP1 and 2 protein levels by as early as two minutes following exposure. Form:Solid |