N-piperidine Ibrutinib hydrochloride
规格
| Cas Number | 2231747-18-3 |
| 规格或纯度 | ≥95% |
| 纯度 | ≥95% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (236.46 mM; Need ultrasonic) H2O : 50 mg/mL (118.23 mM; Need ultrasonic) |
| 过滤标签 | Ligands for Target Protein for PROTAC,Btk,Protein Tyrosine Kinase/RTK,PROTAC |
| 储存温度 | 避光,-20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | N-piperidine Ibrutinib 盐酸盐（化合物 1）是一种可逆的 Ibrutinib 衍生物。N-piperidine Ibrutinib 盐酸盐是一种强效的 BTK 抑制剂，对 WT BTK 和 C481S BTK 的 IC 50 s 分别为 51.0 和 30.7 nM。N-piperidine Ibrutinib hy |
| 英文描述 |
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 ( HY-133137 ). SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM . In Vitro N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK) |