川皮苷
规格
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| Cas编号 | 478-01-3(DMSO) |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (96.69 mM); |
| 简短描述 | MMP Inhibitors |
| 英文简短描述 | MMP Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Nobiletin（NSC 76751，六甲氧基黄酮）是从柑橘皮（如橘子）中分离出来的一种柑橘类黄酮，具有消炎和抗肿瘤活性。 |
| 英文描述 |
Information Nobiletin (NSC 76751) Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation. In vivo LD50: 780mg/kg (i.g.). cell lines：3T3-L1 cells Concentrations： Incubation Time： Powder Purity:≥99% |