NGP 555
规格
| Cas Number | 1304630-27-0 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | γ-分泌酶调节剂 |
| 英文简短描述 | Gamma-secretase Modulators |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | NGP 555 是一种γ-分泌酶的小分子调节剂，在临床前研究中成功地实现了良好的口服吸收、脑穿透、中枢神经系统活性以及对脂质膜靶点的特异性。 |
| 英文描述 |
Information NGP 555 NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically. Targets γ-secretase (Cell-free assay) In vivo NGP 555 has very good brain penetratiobsorption, distribution, metabolism, and excretion (ADME) properties. It efficiently crosses the blood-brain barrier, has a brain:plasma ratio of 0.93 (in Tg2576 mice) and shows in vivo efficacy for lowering the biomarker Aβ42 in rodent studies for brain and plasma. Chronic administration of NGP 555 (milled into chow) to Tg2576 mice results in a significant reduction of amyloid plaques. Cell Research(from reference) Cell lines：SH-SY5Y-APP cells Concentrations：10 nM-100 μM Incubation Time：18 h |