NF-κΒ activator 2
规格
| Cas Number | 2375281-44-8(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | NF-κB,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | NF-κΒ 激活剂 2 是一种强效的口服活性 NF-ҡB 激活剂，其 EC 50 为 1.58 μM。NF-κΒ 激活剂 2 通过增加 NF-ҡB 的表达和激活诱导 SOD 2。NF-κΒ 激活剂 2 可用于肌萎缩性脊髓侧索硬化症的研究 |
| 英文描述 |
NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) In Vitro NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice . NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:NF-κB 1.58 μM (EC 50 ) |