N-piperidine Ibrutinib hydrochloride
规格
| Cas Number | 2231747-18-3(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Ligands for Target Protein for PROTAC,Btk,Protein Tyrosine Kinase/RTK,PROTAC,Compound libraries |
| 储存温度 | 避光,干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | N-piperidine Ibrutinib 盐酸盐（化合物 1）是一种可逆的 Ibrutinib 衍生物。N-piperidine Ibrutinib 盐酸盐是一种强效的 BTK 抑制剂，对 WT BTK 和 C481S BTK 的 IC 50 s 分别为 51.0 和 30.7 nM。N-piperidine Ibrutinib hy |
| 英文描述 |
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 ( HY-133137 ). SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM . In Vitro N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK) |