β-Neo-Endorphin
规格
| Cas Number | 77739-21-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | H2O : 100 mg/mL (90.89 mM; Need ultrasonic) |
| 过滤标签 | MMP,ERK,Stem Cell/Wnt,Metabolic Enzyme/Protease,MAPK/ERK Pathway |
| 储存温度 | 避光,充氩,干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | β-新内啡肽是一种内源性阿片肽。β-新内啡肽是一种源自猪下丘脑的 "大 "亮啡肽。β-内啡肽可激活 Erk1/2、MMP-2 和 MMP-9。 |
| 英文描述 |
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2 , MMP-2 and MMP-9 In Vitro β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes. β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes. β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 20 h Result: Significantly increased the wound closure. Had no observable effect on cell viability. Western Blot AnalysisCell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 12 h Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression. Form:Solid IC50& Target:ERK1 ERK2 MMP-2 MMP-9 |