NS 8593 盐酸盐
规格
| Cas Number | 875755-24-1 |
| 规格或纯度 | ≥98%(HPLC) |
| 纯度 | ≥98%(HPLC) |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 别名 | N-[(1R)-1,2,3,4-四氢-1-萘] -1H-苯并咪唑-2-胺盐酸盐；NS8593 盐酸盐;N- [(1R)-1,2,3,4-四氢-1-萘基]-1H-苯并咪唑-2-胺盐酸盐; |
| 品牌 | 阿拉丁 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 29.98, 最高浓度(mM): 100；溶于ethanol, 最高浓度 (mg/mL): 6, 最高浓度(mM): 20 |
| 简短描述 | KCa2（SK）通道的选择性负调制器；抑制SK电流 |
| 英文简短描述 | Selective negative modulator of KCa2 (SK) channels; inhibits SK currents |
| 过滤标签 | Potassium Channel,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 选择性KCa2（SK）通道负调制器；抑制SK通道电流（在0.5μMCa2 +下，SK1，SK2和SK3的Kd值分别为0.42、0.6和0.73μM）。在KCa1.1（BK），KCa3.1（IK），Kv，Navand Cavchannels上显示SK通道的选择性。抑制海马切片中的超极化后。The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309. |
| 英文描述 |
application： NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells). |