NS3861
规格
| Cas Number | 216853-59-7 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (351.84 mM; Need ultrasonic) |
| 过滤标签 | nAChR,神经元信号传导,膜转运器/离子通道 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | NS3861 是一种烟碱乙酰胆碱受体（nAChRs）激动剂，与异构体 α3β4 nAChR 具有高亲和力。与 α3β4、α3β2、α4β4、α4β2 的结合 K i 值分别为 0.62、25、7.8 和 55 nM。 |
| 英文描述 |
NS3861 is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively. In Vitro NS3861 displays the opposite β-subunit preference and a complete lack of activation at α4-containing receptors in HEK293 cell lines. NS3861 selectively activates α3- but not α4-containing nAChRs and it displays higher efficacy at the α3β2 receptor compared with the α3β4 receptor, with EC 50 s of 1.7 and 0.15 μM for α3β2 and α3β4 receptor, respectively. NS3861 shows high affinity and partial agonist properties in α3β4-expressed nAChRs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |