Org41841
规格
| Cas Number | 301847-37-0(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | TSH Receptor,GPCR/G Protein,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Org41841 是促黄体生成素/绒毛膜促性腺激素受体（LHCGR）和促甲状腺激素受体（TSHR）的部分激动剂，其 EC 50 s 分别为 0.2 和 7.7 μM。 |
| 英文描述 |
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor ( LHCGR ) and thyroid-stimulating hormone receptor ( TSHR ) with EC 50 s of 0.2 and 7.7 μM, respectively. In Vitro Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC 50 s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC 50 of 800 nM. M9 responds to Org41841 with an improved EC 50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR) |