培菲替尼(ASP015K)
规格
| Cas Number | 944118-01-8 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 别名 | 佩非西替尼 |
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| Action Type | 抑制剂 |
| Mechanism Of Action | Janus 激酶 1 抑制剂;Janus 激酶 2 抑制剂;Janus 激酶 3 抑制剂;酪氨酸激酶 2 抑制剂 |
| 简短描述 | JAK2 选择性抑制剂 |
| 英文简短描述 | JAK2 Selective Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Peficitinib（ASP015K，JNJ-54781532）是一种口服生物可利用型 JAK 抑制剂。3期 |
| 描述 |
Peficitinib (ASP015K, JNJ-54781532)是一种口服具有生物活性的 JAK 抑制剂。 |
| 英文描述 |
Information Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailableJAKinhibitor. Phase 3. Targets JAK In vitro ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). In vivo In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. |