(1R,2R)-2-PCCA hydrochloride
规格
| Cas Number | 1609563-71-4(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | GPR88,GPCR/G Protein,Compound libraries |
| 储存温度 | 充氩,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | (1R,2R)-2-PCCA盐酸盐是2-PCCA的非对映异构体，是一种强效的GPR88受体激动剂，在无细胞实验中的EC 50为3 nM，在细胞实验中为603 nM。 |
| 英文描述 |
(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay. In Vitro (1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay . (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC 50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:EC50: 3 nM (GPR88 receptor), 603 nM (GPR88 receptor, in GPR88-22F cells) |