Peptide T
规格
| Cas Number | 106362-32-7 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | H2O : 100 mg/mL (116.57 mM; Need ultrasonic) |
| 过滤标签 | HIV,Anti-infection |
| 储存温度 | 避光,干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 多肽 T 是来自 HIV-1 gp120 V2 区域的八肽。多肽 T 是 CD4 受体的配体，可阻止 HIV 与 CD4 受体结合。 |
| 英文描述 |
Peptide T is an octapeptide from the V2 region of HIV-1 gp120 . Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. In Vitro Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CD4, HIV |