PF-04856264
规格
| Cas Number | 1235397-05-3 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 250 mg/mL (571.44 mM; ultrasonic and warming and heat to 60°C) |
| 过滤标签 | Sodium Channel,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | PF-04856264 是一种强效的选择性 Nav1.7 抑制剂，对人、小鼠、猴和狗 Nav1.7 的 IC 50 s 分别为 28、131、19 和 42 nM。PF-04856264 对大鼠 Nav1.7 通道的效力较低。PF-04856264 具有镇痛作用 |
| 英文描述 |
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC 50 s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect In Vivo PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)Dosage: 3, 30 mg/kg Administration: I.p. Result: Significantly reduced spontaneous pain behaviors in mice. Form:Solid IC50& Target:IC50: 28 (human Nav1.7), 131 nM (mouse Nav1.7), 19 nM (cynomolgus monkey Nav1.7), 42 nM (dog Nav1.7) |