PF 1022A
规格
| Cas Number | 133413-70-4 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 43 mg/mL (45.30 mM) |
| 过滤标签 | Parasite,Anti-infection |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | PF 1022A 是一种具有广谱抗蠕虫特性的环辛二肽，由真菌菌丝体发酵产生。PF 1022A 是一种离子通道形成剂。PF 1022A 在小鼠体内对五倍子蛔虫有很强的驱虫活性。 |
| 英文描述 |
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research . In Vitro PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect. In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |