PIK-108
规格
| Cas Number | 901398-68-3 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 50 mg/mL (137.20 mM; Need ultrasonic) |
| 过滤标签 | PI3K,PI3K/Akt/mTOR |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | PIK-108 是一种非 ATP 竞争性异构 p110β / p110δ 选择性抑制剂。 |
| 英文描述 |
PIK-108 is a non-ATP competitive, allosteric p110β / p110δ selective inhibitor. In Vitro PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Glioma cell lines expressing wild-type PTEN Concentration: 0.1, 0.5, 1, 4, and 10 μM Incubation Time: 1 hour Result: Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines. Form:Solid |