PQ-10
规格
| Cas Number | 927691-21-2 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 25 mg/mL (50.64 mM; Need ultrasonic) |
| 过滤标签 | Phosphodiesterase (PDE),Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | PQ-10是一种强效的磷酸二酯酶10A（PDE10A）抑制剂，其IC 50和ED 50分别为4.6 nM和13 mg/kg。PQ-10 可诱导脑葡萄糖代谢模式，这可能是一种潜在的转化生物标志物。PQ-10有可能成为 |
| 英文描述 |
PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia In Vivo PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice. Form:Solid IC50& Target:PDE10A 4.6 nM (IC 50 ) |