Py-MAA-Val-Cit-PAB-MMAE
规格
| Cas Number | 2247398-68-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (69.12 mM; Need ultrasonic) |
| 过滤标签 | ADC Linker,Antibody-drug Conjugate/ADC Related |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) 是 Zapadcine-3a 的 ADC 链接剂。Zapadcine-3a 是一种抗 TRAILR2 ADC，具有广谱抗肿瘤作用。Zapadcine-3a 可通过与 TRAILR2 结合被吞入肿瘤细胞的溶酶体。T |
| 英文描述 |
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) is an ADC Linker of Zapadcine-3a. Zapadcine-3a is an anti- TRAILR2 ADC with broad spectrum, and antineoplastic effect. Zapadcine-3a can be swallowed up into lysosome of tumor cells by binding to TRAILR2 . Then Zapadcine-3a releases small molecular compound to specifically kill various TRAILR2-pos. Zapadcine-3a potently eradicates tumor cells and cures tumor Form:Solid IC50& Target:CD262 |