Questiomycin A
规格
| Cas Number | 1916-59-2 |
| 规格或纯度 | Moligand™, ≥98% |
| 级别 | Moligand™ |
| 纯度 | ≥98% |
| 包装 | 100mg 或 250mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Soluble in ethanol, methanol, DMF and DMSO. Limited water solubility. |
| 简短描述 | 抑制芳香化酶和硫酸酯酶的吩恶嗪 |
| 英文简短描述 | a phenoxazine that inhibits aromatase and sulfatases |
| 过滤标签 | Antibiotic,Metabolic Enzyme/Protease,Anti-infection |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 物理形态 | 固体 |
| 生化和生理学机理 | Questiomycin A (Phx-3) 是一种 GRP78 (细胞保护性内质网伴侣蛋白) 降解剂，能增强 Sorafenib 的抗癌活性。Questiomycin A 也是一种抗菌剂/抗生素，可从 Pseudomonas chlororaphis HT66的代谢物中获得。 |
| 描述 |
Questiomycin A是由几种链霉菌以及一些真菌和细菌产生的吩恶嗪。Questiomycin A对细菌，真菌，植物和肿瘤细胞系具有弱活性，并抑制芳香酶和硫酸酯酶。Questiomycin与其他phenoxazines一样，在体外刺激细胞生长和更新，其活性可能与其形成稳定自由基的能力有关。最近，已显示出Questiomycin A抑制由小鼠黑素瘤细胞引起的肺转移。Questiomycin A和相关的吩恶嗪是发现研究中重要的重复复制标准，用于消除由于大量弱效活性物质而导致的铅。 |
| 英文描述 |
Questiomycin A is a phenoxazine produced by several|Streptomyces|species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumour cell lines, and inhibits aromatase and sulfatases. Questiomycin, like other phenoxazines, stimulates cell growth and turnover|in vitro|, an activity possibly related to their ability to form stable free radicals. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives. |