(R)-GSK-3685032
规格
| Cas Number | 2170140-50-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 60 mg/mL (142.68 mM; Need ultrasonic) |
| 过滤标签 | 表观遗传学,DNA Methyltransferase |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | (R)-GSK-3685032 是 GSK-3685032 的 R-对映体。GSK-3685032 是一种非时间依赖性、非共价、一流的可逆 DNMT1 选择性抑制剂，IC 50 为 0.036 μM。GSK-3685032 可诱导 DNA 甲基化和转录抑制的强力丧失。 |
| 英文描述 |
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1 -selective inhibitor, with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition Form:Solid IC50& Target:DNMT1 |