R-IMPP
规格
| Cas Number | 2133832-83-2 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg 或 2mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 77 mg/mL (197.69 mM); Ethanol: 77 mg/mL (197.69 mM); Water: 7 mg/mL (17.97 mM); |
| 简短描述 | PCSK9 抑制剂 |
| 英文简短描述 | PCSK9 Inhibitors |
| 过滤标签 | Ser/Thr Protease,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | R-IMPP 是一种 PCSK9 分泌抑制剂，半数最大抑制浓度 [IC50] = 4.8 μM。 |
| 描述 |
R-IMPP (PF-00932239) 是一种 PCSK9 的抗分泌药物 (IC50=4.8 μM)，其靶向 80S 核糖体抑制 PCSK9 蛋白翻译。 |
| 英文描述 |
Information R-IMPP R-IMPP is an inhibitor of PCSK9 secretion, half maximal inhibitory concentration [IC50] = 4.8 μM. Targets PCSK9 In vitro R-IMPP promotes uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but instead causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is discovered that exhibited weak PCSK9 anti-secretagogue activity (half maximal inhibitory concentration [IC50] = 4.8 μM), but does not affect intracellular ATP levels in the recombinant CHO-K1 cells, a measure of cytotoxicity, nor decrease secretion of a control protein, secreted alkaline phosphatase, a measure of relative selectivity. The inhibitory response of R-IMPP is stereospecific. Cell Research(from reference) Cell lines：Huh7 cells Concentrations：10, 30 μM Incubation Time：24 h |