RCM 1

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规格或纯度 10mM in DMSO
货号(SKU) R423471
品牌 阿拉丁
  • 包装

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条款和条件
30天退款保证
运输:2-3 个工作日

规格


Cas Number 339163-65-4
规格或纯度 10mM in DMSO
包装 1ml

产品信息


别名 2-[[[2-氧代-2-(2-噻吩基)乙基]硫代] -4,6-二-2-噻吩基-3-吡啶甲腈
品牌 阿拉丁
浓度 10mM in DMSO
简短描述 FOXM1抑制剂
英文简短描述 FOXM1 inhibitor
过滤标签 Compound libraries
储存温度 -80℃储存
运输条件 超低温冰袋运输
生化和生理学机理 前叉箱M1(FOXM1)转录因子抑制剂(IC50 = 0.72μM)。抑制FOXM1靶基因的表达。在体外诱导FOXM1蛋白降解。在暴露于过敏原的小鼠中,降低气道阻力,增加肺顺应性并减少促炎细胞因子的产生。RCM-1 is a forkhead box M1 (FOXM1) inhibitor that blocks FOXM1 nuclear localization (IC50 = 720 nM using GFP-FOXM1-expressing U2OS cells) and causes FOXM1 degradation via ubiquitination induction (2.9- and 4.8-fold of basal level in A549 cells with 10 μM or 20 μM RCM-1, respectively) without affecting cellular YAP, FACT140, NF-κB, FOXA2, and FOXJ1 levels. RCM-1 intraperitoneal injection (1.7 mg/kg) in mice downregulates endogenous murine FOXM1 level as well as transgenic human FOXM1 GFP fusion level in vivo, effectively suppressing house dust mite-induced lung inflammation as well as goblet cell metaplasia and airway hyperresponsiveness in response to IL-13.
描述

RCM-1 是一种 forkhead box M1 (FOXM1) 抑制剂,在 U2OS 细胞中的 EC50 为 0.72 μM。RCM-1 阻止了核定位并增加了 FOXM1 的蛋白酶体降解。RCM-1 可用于哮喘和其他慢性气道疾病的研究。

技术规格说明书


质检证书(CoA,COO,BSE/TSE)