|
品牌
|
阿拉丁
|
|
Animal free
|
Yes
|
|
Carrier free
|
Yes
|
|
预测分子量
|
48 kDa
|
|
氨基酸
|
24-449 aa
|
|
Protein length
|
蛋白片段
|
|
表达系统
|
HEK293
|
|
生物活性
|
Measured by its binding ability in a functional ELISA. When Recombinant Human LILRA2/CD85h/ILT1 is coated at 2 µg/mL, Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 binds with a typical ED50 of 0.2 -1.2 μg/mL.
|
|
蛋白标签
|
C-His
|
|
序列
|
GHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENHHHHHH
|
|
复溶(Reconstitution)
|
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
|
|
简短描述
|
Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 24-449 aa
|
|
英文简短描述
|
Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 24-449 aa
|
|
稳定性和储存
|
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
|
|
过滤标签
|
CD85,LILRA2,CD85h,ILT1,LIR7,Gene ID: 11027,Accession#: Q8N149
|
|
储存温度
|
-20°C储存,避免反复冻融
|
|
运输条件
|
超低温冰袋运输
|
|
Accession ID
|
Q8N149-1
|
|
物理形态
|
冻干(Lyophilized)
|
|
储存缓冲液
|
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
|
|
内毒素浓度
|
<0.1 EU/μg
|
|
Source
|
重组表达
|
|
英文描述
|
Function
Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens(PubMed:19230061).
|
|
SDS-PAGE
|
60 - 90 kDa, under reducing conditions; 60 - 90 kDa, under non-reducing conditions.
|
