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别名
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Sialic Acid Binding Ig-like Lectin 5; CD170 antigen; CD170; CD33 antigen-like 2; CD33L2; OB binding protein-2; OBBP2; OB-BP2; OB-binding protein 2; OBBP2sialic acid-binding Ig-like lectin 5; Obesity-binding protein 2; sialic acid binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; Siglec5; Siglec-5; SIGLEC5; SIGLEC-5; 重组人Siglec-5蛋白; 重组人唾液酸结合Ig样凝集素5蛋白
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品牌
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阿拉丁
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Cas编号
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Animal free
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Yes
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Carrier free
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Yes
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预测分子量
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74.2 kDa
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氨基酸
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17-434 aa
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Protein length
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蛋白片段
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表达系统
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HEK293
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生物活性
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Measured by the ability of the immobilized protein to support the adhesion of human red blood cells.The ED50 for this effect is 1‑4 µg/mL.
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蛋白标签
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C-hFc & His
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序列
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EKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
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复溶(Reconstitution)
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Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
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简短描述
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Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-hFc&His tag, 17-434 aa
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英文简短描述
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Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-hFc&His tag, 17-434 aa
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稳定性和储存
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在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
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组织特异性
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Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
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结构域
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Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
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过滤标签
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SIGLEC5,Siglec-5,CD170,Gene ID: 8778,Accession#: O15389
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储存温度
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-20°C储存,避免反复冻融
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运输条件
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超低温冰袋运输
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Accession ID
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O15389
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物理形态
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冻干(Lyophilized)
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储存缓冲液
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Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
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内毒素浓度
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<0.1 EU/μg
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Active
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生物活性
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Source
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重组表达
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描述
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英文描述
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Purity
≥95% SDS-PAGE.
Endotoxin level
<0.1 EU/µg
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
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SDS-PAGE
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100 - 120 kDa, under reducing conditions; 200 - 250 kDa, under non-reducing conditions.
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