RMC-6291
规格
| Cas Number | 2641998-63-0 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (98.79 mM; Need ultrasonic) |
| 过滤标签 | Ras,GPCR/G Protein |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | RMC-6291 是一种具有口服活性的 KRAS G12C (ON) 共价抑制剂。RMC-6291 在肿瘤细胞内与 KRAS G12C (ON) 和环嗜蛋白 A (CypA) 形成三重复合物。因此，RMC-6291 通过立体阻断 RAS 效应，阻止 KRAS G12C (ON) 发出信号。 |
| 英文描述 |
RMC-6291 is an orally active and covalent inhibitor of KRAS G12C (ON) . RMC-6291 forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRAS G12C (ON) from signaling via steric blockade of RAS effector binding. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRAS G12C tumor models Form:Solid IC50& Target:KRAS(G12C) |